Bi bider ohikoagoa da depresioaren diagnosia emakumeengan gizonezkoetan baino, eta, ondorioz, baita farmako antidepresiboen erabilera ere. Hala ere, estresarekin lotutako nahasteen eta haien tratamenduaren inguruko ikerketa gehienak animalia arretan egiten dira, eta ikerketetako emaitzak gizon nahiz emakumeetara orokortzen dira gero. Ildo horretatik, antsietatearen eta depresioaren aurkako tratamenduen eraginkortasuna sexuaren araberakoa da, berezitasun biologikoak izaki. Hori dela-eta, lan honek ezegonkortasun sozial kronikoaren estresa bizi duten sagu emeen jokabidean eta garuneko bide serotoninergikoan benlafaxinak —serotoninaren eta noradrenalinaren birkaptazioaren inhibitzailea— duen eragina du aztergai.

Gako-hitzak: Emeak, Estresa, Jokabidea, Benlafaxina, Depresioa

Women are twice as likely as men to develop depression, and are also more frequently prescribed antidepressant treatments. This sexual disparity is also observable in effectiveness of treatments. Despite this fact, most studies that have used animal models to determine the physiological mechanisms implicated in depression and to develop specific drugs for their treatment have been performed in males. The aim of this study was to analyze the effects of the serotonine and noradrenaline reuptake inhibitor venlafaxine on the behavior and central serotoninergic pathways of female mice subjected to chronic social instability stress.

Keywords: Female, Stress, Behavior, Venlafaxine, Depression